- Title
- An immune atlas of clear cell renal cell carcinoma
- Creator
- Chevrier, Stephane; Levine, Jacob Harrison; van den Broek, Maries; Beisel, Christian; Stadler, Michael Beda; Gedye, Craig; Reis, Bernhard; Pe'er, Dana; Bodenmiller, Bernd; Zanotelli, Vito Riccardo Tomaso; Silina, Karina; Schulz, Daniel; Bacac, Marina; Ries, Carola Hermine; Ailles, Laurie; Jewett, Michael Alexander Spencer; Moch, Holger
- Relation
- Cell Vol. 169, Issue 4, p. 736-749
- Publisher Link
- http://dx.doi.org/10.1016/j.cell.2017.04.016
- Publisher
- Cell Press
- Resource Type
- journal article
- Date
- 2017
- Description
- Immune cells in the tumor microenvironment modulate cancer progression and are attractive therapeutic targets. Macrophages and T cells are key components of the microenvironment, yet their phenotypes and relationships in this ecosystem and to clinical outcomes are ill defined. We used mass cytometry with extensive antibody panels to perform in-depth immune profiling of samples from 73 clear cell renal cell carcinoma (ccRCC) patients and five healthy controls. In 3.5 million measured cells, we identified 17 tumor-associated macrophage phenotypes, 22 T cell phenotypes, and a distinct immune composition correlated with progression-free survival, thereby presenting an in-depth human atlas of the immune tumor microenvironment in this disease. This study revealed potential biomarkers and targets for immunotherapy development and validated tools that can be used for immune profiling of other tumor types.
- Subject
- immune cells; carcinoma; T cells; microenvironments
- Identifier
- http://hdl.handle.net/1959.13/1399497
- Identifier
- uon:34616
- Identifier
- ISSN:0092-8674
- Rights
- This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
- Language
- eng
- Full Text
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| Thumbnail | File | Description | Size | Format | |||
|---|---|---|---|---|---|---|---|
| View Details Download | ATTACHMENT02 | Publisher version (open access) | 7 MB | Adobe Acrobat PDF | View Details Download |